All Compounds
11 compounds cataloged with risk profiles and natural alternatives
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Browse Compounds by Goal
Cognitive Enhancement
Cognition & Longevity
Improving focus, memory, learning, and mental clarity.
Improve attention, memory, and mental stamina with lower-risk options.
Muscle Growth
Performance
Building lean muscle mass through training and nutrition optimization.
Build lean mass with evidence-backed training, protein, and recovery basics.
Sleep Quality
Recovery & Wellness
Improving sleep onset, duration, and quality of deep sleep.
Improve deep sleep, recovery quality, and next-day performance.
9-ME-BC
High RiskBeta-carboline that increases dopaminergic neuron differentiation and neurotrophic factors. Neuroprotective claims.
Alpha-GPC
Low RiskHighly bioavailable choline source that crosses the BBB. Precursor to acetylcholine synthesis.
Bromantane
Moderate RiskAtypical stimulant that upregulates tyrosine hydroxylase and aromatic amino acid decarboxylase, increasing dopamine synthesis.
Methylene Blue
Low RiskMitochondrial electron carrier that enhances Complex IV activity and acts as an alternative electron carrier in the ETC.
Modafinil
Low RiskEugeroic (wakefulness-promoting agent) that inhibits dopamine reuptake and modulates GABA/glutamate.
Noopept
Low RiskCycloprolylglycine prodrug with 1000x potency of piracetam. Modulates AMPA and NMDA receptors, increases BDNF/NGF.
NSI-189
Moderate RiskNeurogenic compound that promotes hippocampal neurogenesis. Developed for major depressive disorder.
Phenibut
High RiskGABA-B agonist and voltage-dependent calcium channel blocker. Crosses BBB unlike regular GABA.
Phenylpiracetam
Low RiskPiracetam derivative with added phenyl group. Increases dopamine receptor density and provides stimulant-like effects.
Piracetam
Low RiskOriginal racetam nootropic. Modulates AMPA receptors and improves membrane fluidity. Enhances cerebral blood flow.
Tianeptine
High RiskAtypical antidepressant with mu-opioid receptor agonism at high doses. Glutamate modulation.
About Our Compound Database
NaturalOverNeedles maintains one of the most comprehensive databases of peptides, SARMs, GLP-1 receptor agonists, nootropics, and research chemicals available online. Each compound is cataloged with detailed risk profiles, mechanism of action, typical dosages, FDA status, and most importantly — evidence-graded natural alternatives.
Our mission is to help you make informed decisions about your health by providing transparent, research-backed information about both synthetic compounds and their natural counterparts.