Our Methodology
How we evaluate compounds, grade evidence, and match natural alternatives.
Evidence Grading System
Each natural alternative is assigned an evidence grade (A through D) based on the quality, quantity, and consistency of available scientific evidence.
Grade A — Strong Evidence
Multiple randomized controlled trials (RCTs), meta-analyses, or systematic reviews supporting efficacy. Consistent results across diverse populations.
Grade B — Moderate Evidence
At least one well-designed RCT or multiple controlled studies. Generally consistent findings but may have some limitations in study design or sample size.
Grade C — Limited Evidence
Observational studies, case reports, or animal studies suggesting benefit. Human evidence is preliminary or inconsistent.
Grade D — Preliminary Evidence
In-vitro studies, theoretical mechanisms, or traditional use only. Insufficient human data to make strong claims. Included for completeness.
Risk Assessment
Every compound is assigned a risk level (high, moderate, or low) based on multiple factors:
- FDA regulatory status — Approved drugs vs. research-only compounds vs. unregulated substances
- Known side effects — Severity, frequency, and reversibility of documented adverse effects
- Quality of human safety data — Whether long-term human safety studies exist
- Administration route — Injectable compounds carry additional risks vs. oral or topical
- Potential for misuse — Abuse potential, dependency risk, and hormonal disruption
Content & Data Sources
Our compound and alternative database is compiled from:
- PubMed and peer-reviewed scientific literature
- Examine.com and other evidence-based databases
- FDA drug databases and regulatory filings
- Clinical trial registries (ClinicalTrials.gov)
- Community reports from Reddit and biohacking forums
AI-assisted content is used for article generation and is always reviewed for accuracy. Community reviews are published without moderation and represent individual experiences, not medical advice.